Pyelonephritis XV. Long-term study of ascending Escherichia coli pyelonephritis in mice.

Keane and Freedman (1) demonstrated that diuresis produced by feeding 5% glucose rendered mice susceptible to acute ascending pyelonephritis with Escherichia coli. We reported the use of this model in therapeutic studies of E. coli (2) and Proteus mirabilis (3) pyelonephritis. The present investigation, a bacteriologic, immunologic, and pathologic study of long-term infection with E. coli shows that pyelonephritis persisted and progressed for the duration of the study (32 wk).